mRNA Vaccines - Researchers Propose A Design Fix

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mRNA Vaccines - Researchers Propose A Design Fix An article on University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics." If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special/ Want to support this work?: Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true PayPal: https://paypal.me/mobeensyed?locale.x=en_US My substack: https://mobeensyedmd.substack.com/ #drbeen #koolbeens #COVID Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. URL list from Friday, Dec. 8 2023 Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature https://www.nature.com/articles/s41586-023-06800-3 The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next. Ribosomes, Transcription, Translation | Learn Science at Scitable https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized. Genetic code - Wikipedia https://en.wikipedia.org/wiki/Genetic_code DNA and RNA codon tables - Wikipedia https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables Pseudouridine - Wikipedia https://en.wikipedia.org/wiki/Pseudouridine Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science https://pubs.acs.org/doi/10.1021/acscentsci.1c00197 Ribonucleotide - Wikipedia https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA. Translation: DNA to mRNA to Protein | Learn Science at Scitable https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life. Frontiers | On programmed ribosomal frameshifting: the alternative proteomes https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift).

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00:03:06

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00:51

Flashback - Dr. Janette Nesheiwat: Masks In Schools And 'The Science'

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Posted • November 24, 2024: In the grand scheme of things, "Surgeon General" is a wasteful and often counterproductive (assuming the goal is actually improving public health and not advancing special interests) position that Trump should do away with entirely. No one needs a sleazy bureaucrat in a silly admiral costume using their tax money to tell them how to live their lives — much less issuing pseudoscientific edicts for unclear and nefarious purposes, as we have been subject to for many years now. What we need, in my opinion and apparently many other Americans’ given the recent election results, is a bulldog like RFK Jr., doctor or not, to clean up the water, air, drug, and food supplies through — and I know this is anathema to conservative orthodoxy, but I believe it’s necessary in the real world with bad industry actors who don’t care about human health and often, indeed, seem hellbent on ruining it — regulations that make sense and that are applied honestly and aggressively.

But anyway, if this government bloat is to continue in perpetuity, the Surgeon General ought rightly to be someone exactly not like Janette Nesheiwat, Trump’s nominee. Nesheiwat, who specialized in emergency and family medicine, has supported vaccines that Robert F. Kennedy Jr., Trump’s nominee for HHS secretary, has cast doubts about. Janette has not just “supported vaccines”; she has actively promoted and praised censorship of dissident voices on the topic in the alleged service of Public Health™. She called the COVID “vaccines” — which are not now and never were real vaccines and which killed and maimed more people than we can perhaps ever fully account for — a “gift from God.” https://pbs.twimg.com/media/GdB_7k9WYAA4Toj?format=jpg&name=large

She also fearmongered in 2021 on nominally conservative Fox News with no pushback from the “journalist” interviewing her about COVID “putting our children in the hospital in record numbers” and, as a result, hospitals were “running out of ICU beds.” Both claims were lies. None of this garbage is what American voters signed off on when they elected Trump. (…)

• More at: PJ Media - Trump Really Screwed the Pooch With His Surgeon General Nomination
https://pjmedia.com/benbartee/2024/11/24/trump-really-screwed-the-pooch-with-his-surgeon-general-nomination-n4934584
Politico: Trump chooses Fox News contributor Dr. Janette Nesheiwat for surgeon general
https://www.politico.com/news/2024/11/22/trump-chooses-fox-news-contributor-dr-janette-nesheiwat-for-surgeon-general-00191379

00:05:15

Politicians for the people

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,Mr. Russell Broadbent, MP https://russellbroadbent.com.au Letter to Anthony Albanese, Australian Prime Minister https://russellbroadbent.com.au/australiansdemandanswers/ Mr Broadbent on X, https://twitter.com/BroadbentMP Great discussion with Mr. Russell Broadbent MP. A politician who advocates for and correctly represents his constituents and the wider world. Thank you. … our fathers brought forth on this continent, a new nation, conceived in Liberty, and dedicated to the proposition that all men are created equal. … and that government of the people, by the people, for the people, shall not perish from the earth. Abraham Lincoln November 19, 1863 The Hon Anthony Albanese MP Prime Minister Parliament House CANBERRA ACT 2600 By email: parliament@pm.gov.au Dear Prime Minister I refer to my letter of 20 September 2024 calling on the government to immediately suspend the use of Pfizer and Moderna Covid-19 products due to the evidence of significant synthetic DNA contamination, as detailed in Dr. David Speicher’s report. Unlike the Thalidomide tragedy, which resulted in over 10,000 victims globally, the Covid-19 vaccines have been administered to more than 20 million Australians, totalling over 63 million doses. The contamination detected in these vaccines, if not addressed, presents a substantial risk, with the potential for these dangers - such as genomic integration and potential long-term health impacts - to multiply with each additional dose administered. Immediate action through a suspension of these products is critical to mitigate further risk. To assist in adopting a precautionary approach and minimizing further harm, I enclose a Science Summary created and endorsed by eminent Australian and international scientists and medical experts. The summary reinforces the known and potential dangers of DNA contamination and highlights the need for an urgent and independent investigation. As advised by the co-signatories, the Department of Health and Aged Care has produced no evidence to demonstrate why the detected DNA contamination will not produce the dire adverse health outcomes detailed in the Science Summary. Additionally, I have reason to believe that multiple attempts by prominent scientists to warn the TGA of these risks have been disregarded since early 2021, raising serious questions about the agency's ability to protect the health and well-being of Australians. Finally, I draw your attention to the Biosecurity Act 2015, which may now be relevant. Given the contamination evidence, I recommend the Minister for Agriculture initiate a Biosecurity Import Risk Analysis of these products, potentially leading to the suspension of these products due to the risks they pose to human health. I gratefully acknowledge the assistance of the 52 co-signatories below in the preparation of this letter and reiterate my call seeking your urgent action to ensure the safety of all Australians. Yours sincerely Russell Broadbent MP Member for Monash

00:11:56

Los Angeles Failed Monorail Plan

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15K views 3 days ago

,Thank you to Holzkern for sponsoring this video! Click my link http://www.holzkern.com/itshistory to save up to 30% site-wide in their biggest sale of the year—limited time only! 00:00 - Disney’s Monorail Dream 01:19 - The Cutting Edge of Urban Transit 02:29 - A Grand Opening at Disneyland 03:45 - The Roots of the Monorail Concept 05:00 - Walt Disney and Axel Wenner-Gren Collaborate 06:18 - From Disneyland to LA: A Bold Proposal 07:44 - Opposition and the Death of the LA Monorail 09:08 - The Legacy of Disney’s Monorail 10:27 - A Visionary’s Urban Transit Dream Why doesn’t Los Angeles have a monorail? In this episode of It’s History, we dive into Disney’s ambitious plan to transform LA’s transportation network with a futuristic monorail system. Discover how Walt Disney’s innovative vision aimed to solve LA’s traffic problems and why it ultimately failed. From behind-the-scenes politics to logistical challenges, we uncover the untold story of Disney’s monorail dream and the lasting impact it could have had on Los Angeles. Join us as we explore the history of this ambitious project, the opposition it faced, and how it fits into the broader story of urban transportation in the United States. Don’t forget to like, comment, and subscribe for more fascinating stories about the history of cities, transportation, and iconic innovations! Support us on the Patreon 👉 https://patreon.com/RyanSocash Support the Channel by becoming a member 👉 https://youtube.com/channel/UCzIZ8HrzDgc-pNQDUG6avBA/join #LosAngelesHistory #DisneyMonorail #UrbanTransportation #MonorailHistory #FailedProjects #DisneyHistory #TransportationFails #LosAngelesTraffic #UrbanPlanning #ItsHistory IT’S HISTORY - Weekly Tales of American Urban Decay as presented by your host Ryan Socash. https://www.youtube.com/playlist?list=PL2NN2rktA4yMZ4vmNaA3KpsS5KXLj3xVN » Subscribe: https://youtube.com/@ITSHISTORY?sub_confirmation=1 » Listen podcasts: https://ffm.bio/itshistory » CONTACT For brands, agencies, and sponsorships: itshistory@thoughtleaders.io Click here to book a sponsorship with me thoughtleaders.io/reserve/its-history » CREDIT Editor - Karolina Szwata Host - Ryan Socash Music/Sound Design: Dave Daddario » NOTICE Some images may be used for illustrative purposes only - always reflecting the accurate time frame and content. Events of factual error / mispronounced word/spelling mistakes - retractions will be published in this section.

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The Most Dangerous Symptom of a Magnesium Deficiency

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,Did you know that magnesium deficiency can lead to some of the most dangerous health issues? In this video, we reveal the most dangerous symptom of magnesium deficiency that you MUST watch out for! Magnesium is a crucial mineral for your body, affecting everything from heart health to your nervous system and muscle function. But if you're deficient, it can cause severe symptoms that often go unnoticed—until it's too late. #magnesiumsupplement #magnesiumdeficiency #magnesium #drberg Dr. Eric Berg DC Bio: Dr. Berg, age 59, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. Follow Me On Social Media: Facebook: https://bit.ly/FB-DrBerg Instagram: https://bit.ly/IG-DrBerg Listen to my Podcast: https://bit.ly/drberg-podcast TikTok: https://bit.ly/TikTok-DrBerg Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. #keto #ketodiet #weightloss #ketolifestyle

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Javier Milei: President of Argentina - Freedom, Economics, and Corruption | Lex Fridman Podcast #453

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2M views 1 week ago

,Javier Milei is the President of Argentina. This episode is available in both English and Spanish. Thank you for listening ❤ Check out our sponsors: https://lexfridman.com/sponsors/ep453-sb See below for timestamps, transcript, and to give feedback, submit questions, contact Lex, etc. *Update: 3rd Audio Track with Original Audio:* I've added a 3rd audio track with the original audio, with Lex speaking English and Javier Milei speaking Spanish. To listen to it, please choose "English (United Kingdom)" audio track, by clicking on: Settings (Gear Icon), Audio Track, Choose: English (United Kingdom). So, "English (US)" is the fully english dubbed track, and "English (UK)" is the original bilingual track. For the latter, you can turn on subtitles as well. For now, this is the best I can do. I will work with the YouTube team to figure out a better solution. I tried really hard to make this conversation as accessible as possible to people who speak only English or Spanish. I'll keep trying to figure out how to do this better. Your feedback is deeply appreciated. Thank you for listening. I love you all! ❤ *Corrections/Clarifications in Translation:* - The English translation at 23:23 says "fiscal deficit" when it should say "fiscal balance". We fixed the captions, transcript, and will try to fix the audio soon 🙏 - A few times "liberal" is mentioned. In most of the world (except US) that means "classical liberal" which in US is better understood as "libertarian". *Switch between English & Spanish Versions:* This podcast is translated and dubbed into Spanish. To switch between English & Spanish, click: Settings (Gear Icon) , Audio Track , Choose Language. Thank you to ElevenLabs for their amazing help with translation & dubbing 🙏' *Transcript:* https://lexfridman.com/javier-milei-transcript *CONTACT LEX:* *Feedback* - give feedback to Lex: https://lexfridman.com/survey *AMA* - submit questions, videos or call-in: https://lexfridman.com/ama *Hiring* - join our team: https://lexfridman.com/hiring *Other* - other ways to get in touch: https://lexfridman.com/contact *EPISODE LINKS:* Javier Milei's X: https://x.com/JMilei Javier Milei's Instagram: https://instagram.com/javiermilei Javier Milei's Facebook: https://facebook.com/JavierMileiEconomista *SPONSORS:* To support this podcast, check out our sponsors & get discounts: *Eight Sleep:* Temp-controlled smart mattress. Go to https://lexfridman.com/s/eight_sleep-ep453-sb *NetSuite:* Business management software. Go to https://lexfridman.com/s/netsuite-ep453-sb *BetterHelp:* Online therapy and counseling. Go to https://lexfridman.com/s/betterhelp-ep453-sb *AG1:* All-in-one daily nutrition drinks. Go to https://lexfridman.com/s/ag1-ep453-sb *LMNT:* Zero-sugar electrolyte drink mix. Go to https://lexfridman.com/s/lmnt-ep453-sb *OUTLINE:* 0:00 - Introduction 3:27 - Economic freedom 8:52 - Anarcho-capitalism 18:45 - Presidency and reforms 38:05 - Poverty 44:37 - Corruption 53:14 - Freedom 1:07:26 - Elon Musk 1:12:54 - DOGE 1:14:56 - Donald Trump 1:20:56 - US and Argentina relations 1:28:05 - Messi vs Maradona 1:36:58 - God 1:39:05 - Elvis and Rolling Stones 1:42:45 - Free market 1:49:46 - Loyalty 1:52:23 - Advice for young people 1:53:49 - Hope for Argentina *PODCAST LINKS:* - Podcast Website: https://lexfridman.com/podcast - Apple Podcasts: https://apple.co/2lwqZIr - Spotify: https://spoti.fi/2nEwCF8 - RSS: https://lexfridman.com/feed/podcast/ - Podcast Playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4 - Clips Channel: https://www.youtube.com/lexclips *SOCIAL LINKS:* - X: https://x.com/lexfridman - Instagram: https://instagram.com/lexfridman - TikTok: https://tiktok.com/@lexfridman - LinkedIn: https://linkedin.com/in/lexfridman - Facebook: https://facebook.com/lexfridman - Patreon: https://patreon.com/lexfridman - Telegram: https://t.me/lexfridman - Reddit: https://reddit.com/r/lexfridman

00:07:40

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4K views 1 week ago

,Imagine causing a sinkhole that collapses the Washington Monument? Subscribe to TDC: https://www.youtube.com/TheDailyConversation/ Main Sources: DC Flood Risks https://www.washingtonpost.com/climate-environment/interactive/2023/dc-low-lying-city-flood-risks/ Potomac Basin https://potomacdwspp.org/resources/about-the-potomac-basin/ Flood proofing Federal Triangle https://www.youtube.com/watch?v=goFC7H8DN5o CBS: Rising Waters in Tidal Basin https://www.youtube.com/watch?v=CPLedIobHRw New Flood Wall https://youtu.be/XMFcJ_ttSZI?si=1clHozSB2nlmKnV4&t=62 DC Water's Clean Rivers PDF https://www.dcwater.com/sites/default/files/project/2016-12/presentations/2024-04-10%20WABA%20%28WPP%29%20Briefing%20Presentation.pdf DC Clean Rivers video https://www.youtube.com/watch?v=bCOXuWgPnXw Lady Bird Tunnel Boring Machine https://youtu.be/J5oEqtpB1go?si=1LgeBHozH_k9x1_u&t=69 Tour of Blue Plains Wastewater Treatment Plant https://youtu.be/Rm_iyxwAx94?si=NCL1T0C_B-RLsOCY That nightmare scenario haunted the team excavating the 75 foot-deep site for the National Museum of African American History and Culture after they accidentally hit the aquifer under the National Mall. If too much water gushed into their giant pit, they could destabilize their neighbor, the great structure just a few hundred feet away, causing it to shift or even fall over. So they acted quickly to pump water back in to stabilize it. When their instruments showed the ground pressure holding firm, they plugged up the leak and focused on modifying the museum’s design to mitigate this new risk. To maximize its exhibit space, while limiting its above ground footprint, the museum’s first four levels are underground. To keep them dry, visitors safe, and the 91,000-ton monument next door standing tall, they encased the subterranean levels in two walls, with eight feet of porous stone fill in between, to catch and hold any water that might penetrate the foundation. It was an ingenious solution, but for builders in the federal District of Columbia, dealing with a shallow water table is nothing new. When President George Washington chose this idyllic spot to be the national capital, it was a land of farms and woods, rich with surface water. Small brooks trickled into streams, like Rock Creek. Marshes and tidal flats swelled and receded as the 14,700 square-mile Potomac basin drained through the District and mixed with the tidal flow of the Chesapeake Bay–the largest estuary in the United States. But as the city's boulevards and grand buildings were constructed over the past two-and-a-half centuries, 70% of these natural streams have disappeared: diverted into sewers, culverts, or filled in and paved over. Tiber Creek flowed through what has become the National Mall. First, it was converted into a canal, and then piped into sewers buried beneath Federal Triangle. Today, this group of large neoclassical buildings - between Constitution and Pennsylvania Avenues - is home to numerous large government agencies. It’s also the lowest point in downtown. In 2006 it rained heavily for an entire week, leaving the Triangle submerged, causing tens of millions of dollars in damage and disrupting government operations. It wasn’t the first time this has happened here. Experts fear the most extreme storm would put the American History Museum under 16 feet of water. Engineers have taken steps to protect the buildings, like installing temporary barriers, retractable gates, and raising core utilities out of their basements. There’s even now a temporary levee that’s trucked over and dropped in along the Mall for added protection ahead of big storms. But throughout the rest of DC, an estimated 16,000 homes and businesses have had little protection from flooding when it rains. Some residents have water gush in from the street, others confront it bubbling up from their toilets when old sewers overflow and long-buried “zombie” streams gurgle back to life. On the southernmost edge of the district, along the Potomac, another major flooding threat looms. Over the past century, the waterline has effectively risen four feet, a combination of sea level rise and the land sinking under the weight of development. I’ve definitely noticed the water getting a little higher every year. The area where the water is is actually a portion of the seawall that has settled over the years. During high tide, when the ocean pushes the Chesapeake Bay further up the Potomac, 250 million gallons of river water enter the Tidal Basin. But it was constructed in 1897, it can no longer contain the river at high tide, causing the walking paths around the monuments and iconic cherry trees to flood twice a day like clockwork. Atlanta Megacity Megacities Detroit Pittsburgh Philadelphia Delhi Los Angeles Chicago Lincoln memorial capital one Georgetown highlights commanders wizards capitals art museum national history natural history Smithsonian MLK Obama Mall Metro FDR Jefferson

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This Abandoned Palace Has a Dark WWII Secret

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,Hidden in the forests of northeast Poland lies the haunting remains of Schlobitten Palace, a once-majestic estate with a rich and turbulent history. Originally built in the 17th century, this sprawling palace was a symbol of Prussian aristocracy and home to the wealthy Dohna-Schlobitten family for generations. However, its story took a dark turn during World War II when it was abandoned in the chaos of war. Join us as we explore the eerie, decaying hallways and forgotten rooms that have stood silent for decades. We’ll uncover the secrets of Schlobitten Palace’s tragic past, delve into its role in WWII, and reveal how it became a ghostly relic of a bygone era. In this episode, we’re stepping back in time to uncover: • The rise and fall of the Prussian aristocracy • How Schlobitten Palace became a victim of wartime devastation • The hidden architectural treasures still visible among the ruins This journey into history is both fascinating and unsettling—a reminder of how time and conflict can transform even the grandest of places into haunting shadows of their former glory. #AbandonedPlaces #WWIIHistory #Poland #SchlobittenPalace #HauntedHistory #LostEmpires #PrussianHistory #EuropeanRuins #HistoricExploration #It’sHistory Support us on the Patreon 👉 https://patreon.com/RyanSocash Support the Channel by becoming a member 👉 https://youtube.com/channel/UCzIZ8HrzDgc-pNQDUG6avBA/join IT’S HISTORY - Weekly Tales of American Urban Decay as presented by your host Ryan Socash. https://www.youtube.com/playlist?list=PL2NN2rktA4yMZ4vmNaA3KpsS5KXLj3xVN » Subscribe: https://youtube.com/@ITSHISTORY?sub_confirmation=1 » Listen podcasts: https://ffm.bio/itshistory » CONTACT For brands, agencies, and sponsorships: itshistory@thoughtleaders.io Click here to book a sponsorship with me thoughtleaders.io/reserve/its-history » CREDIT Scriptwriter - Ryan Socash Editor - Kamil Krawiec Host - Ryan Socash Guest Host - Dr. Hubert Baumann Music/Sound Design: Dave Daddario » NOTICE Some images may be used for illustrative purposes only - always reflecting the accurate time frame and content. Events of factual error / mispronounced word/spelling mistakes - retractions will be published in this section.

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,In this webinar, we will address commonly asked questions recently sent to the Dlubal support team regarding RFEM 6 and RSTAB 9. Time Schedule: 00:00 Introduction 01:15 How can I exclude objects from the design of individual combinations? 04:20 How can I create a pre-deformed FE mesh like I used to in RF-IMP? 11:30 Can I automatically consider the stiffnesses of steel joints in the global RFEM model? 18:00 How can I adjust the stiffness of objects? 23:10 How can I analyze a pile? 28:35 How can I use combinatorics for road bridges? More on Dlubal Software Website: ► https://www.dlubal.com/en-US/support-and-learning/learning/videos/005167 Watch our webinars and videos to improve your knowledge of Dlubal software and find new ways to work more efficiently. ► Webinars: https://www.dlubal.com/en-US/support-and-learning/learning/webinars ► Videos: https://www.dlubal.com/en-US/support-and-learning/learning/videos Did you find this video helpful? ► Let us know in the comments if you like this video. E-Learning videos: ► RFEM 6 for Beginners: https://www.youtube.com/playlist?list=PL8ofwN6MZdI_JsyH5qaHA1itUfXa7w8sR ► Programming with RFEM 6 and Python: https://www.youtube.com/playlist?list=PL8ofwN6MZdI85JiM-9rcL_x47muHsoqR6 ► RFEM 6 Tutorial with Rhino & Grasshopper: https://www.youtube.com/playlist?list=PL8ofwN6MZdI9kCA-3urTuraG1HW1jK3MO Take advantage of our free support. Do you have any questions? ► Frequently Asked Questions (FAQ): https://www.dlubal.com/en/support-and-learning/support/faq ► Ask an individual question: https://www.dlubal.com/en/support-and-learning/support/ask-individual-question ► Knowledge Base: https://www.dlubal.com/en-US/support-and-learning/support/knowledge-base Follow us and stay up to date: ► Subscribe to the Dlubal YouTube Channel: https://www.youtube.com/user/DlubalEN?sub_confirmation=1 ► Instagram: https://www.instagram.com/dlubal_software/ ► Are you also on Facebook? Follow us here: https://www.facebook.com/dlubal.software.english Keywords #DlubalWebinar #FreeWebinar #Webinar #RFEM6 #RSTAB9 #UserQuestions #Support #FAQ #WebinarOnDlubalSoftware #DlubalTutorial #Construction #StructuralEngineering #CivilEngineer #StructuralDesign #StructuralEngineer #StructuralAnalysis #DlubalSoftware

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,Question: How do I include the redundancy factor(s) ρ in the ASCE 7 load combinations? Answer: 1) Open the ''Load Cases & Combinations'' dialog box. Under the ''Base'' tab, select the ''Edit Parameters of Edition'' option. The default values are set to 1.0 (Image 01) ► Image | Redundancy Factors https://www.dlubal.com/en/img/034340 Case A: To apply the same factor in the X and Y directions, use the generic (no direction) redundancy factor, ρ. Case B: To apply different factors in each direction, use the redundancy factors, ρ-x and ρ-y. The generic factor ρ in the first row is not used. 2) Under the ''Load Cases'' tab, create a seismic load case with Qe as the ''Action Category''. Next, select the ''Additional Settings'' tab and pick the direction (Image 02) ► Image | Create Seismic Load Case https://www.dlubal.com/en/img/033443 3) Under the ''Design Situations'' tab, select the applicable seismic Design Situation Type. Both LRFD and ASD methods are available (Image 03) ► Image | Seismic Design Situations https://www.dlubal.com/en/img/034342 '''Note:''' When neither or both directions are activated under the '''same''' load case, the generic redundancy factor ρ is used. Create a '''separate''' load case to apply the individual factors, ρ-x and ρ-y. 4) In the ''Load Combinations'' tab, verify that the correct factor(s) have been applied. Factors are also shown in the ''Result Combinations'' tab, if applicable. Click OK to exit (Image 04) ► Image | Load Combination Including Redundancy Factor https://www.dlubal.com/en/img/034343 For more information, go to the FAQ page: ► https://www.dlubal.com/en-us/support-and-learning/support/faq/005319 Did you find this video helpful? ► Let us know in the comments if you like this video. E-learning videos: ► RFEM 6 for beginners: https://www.youtube.com/playlist?list=PL8ofwN6MZdI_JsyH5qaHA1itUfXa7w8sR ► Programming with RFEM 6 and Python: https://www.youtube.com/playlist?list=PLx7dtCtXeyHWXCU3Q6NMHkKwRgWgLb-Da ► RFEM 6 tutorial with Rhino & Grasshopper: https://www.youtube.com/playlist?list=PLx7dtCtXeyHX5toT2EXyV5nvc0E0fHWKJ Take advantage of our free support. Do you have any questions? ► Frequently Asked Questions (FAQ): https://www.dlubal.com/en/support-and-learning/support/faq ► Ask an individual question: https://www.dlubal.com/en/support-and-learning/support/ask-individual-question ► Knowledge Base: https://www.dlubal.com/en-US/support-and-learning/support/knowledge-base Follow us and stay up to date: ► Subscribe to the Dlubal YouTube Channel: https://www.youtube.com/user/DlubalEN?sub_confirmation=1 ► Instagram: https://www.instagram.com/dlubal_software/ ► Are you also on Facebook? Follow us here: https://www.facebook.com/dlubal.software.english Keywords #DlubalFAQ #RedundancyFactor #ASCE7 #LoadCombination #SeismicLoadCase #Earthquake #FrequentlyAskedQuestion #FAQAboutDlubalSoftware #QuestionAndAnswerToDlubalSoftware

00:00:56

FAQ 005320 | How do I include the overstrength factor(s) Ω-o in the ASCE 7 load combinations?

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,Question: How do I include the overstrength factor(s) Ω-o in the ASCE 7 load combinations? Answer: 1) Open the ''Load Cases & Combinations'' dialog box. Under the ''Base'' tab, select the ''Edit Parameters of Edition'' option. The default values are set to 2.0 (Image 01) ► Image | Edit Parameters of Edition https://www.dlubal.com/en/img/033442 Case A: To apply the same factor in the X and Y directions, use the generic (no direction) overstrength factor Ω-o. Case B: To apply different factors in each direction, use the overstrength factors X and Y, Ω-o,x and Ω-o,y. The generic factor Ω-o in the first row is not used. 2) Under the ''Load Cases'' tab, create a seismic load case with Qe as the ''Action Category''. Next, select the ''Additional Settings'' tab and pick the direction (Image 02) ► Image | Create Seismic Load Case https://www.dlubal.com/en/img/033443 '''Note:''' When neither or both directions are activated under the '''same''' load case, the generic overstrength factor, Ωo is used. Create a '''separate''' load case to apply the individual factors, Ω-o,x and Ω-o,y. 3) Under the ''Design Situations'' tab, select the applicable overstrength Design Situation Type. Both LRFD and ASD methods are available (Image 03) ► Image | Overstrength Design Situations https://www.dlubal.com/en/img/033444 4) In the ''Load Combinations'' tab, verify that the correct factor(s) have been applied. Factors are also shown in the ''Result Combinations'' tab, if applicable. Click OK to exit (Image 04) ► Image | Verify the Overstrength Factor https://www.dlubal.com/en/img/033445 5) The final step is to assign the applicable limit state type to the overstrength design situation. For members '''without''' assigned seismic configuration, select the "Strength limit state" (LRFD or ASD) as the ''Limit State Type''. For members '''with''' assigned seismic configuration, use “Earthquake limit state – overstrength” (LRFD or ASD) (Image 05) ► Image | Overstrength Limit State Type https://www.dlubal.com/en/img/033446 For more information, go to the FAQ page: ► https://www.dlubal.com/en-us/support-and-learning/support/faq/005320 Did you find this video helpful? ► Let us know in the comments if you like this video. E-learning videos: ► RFEM 6 for beginners: https://www.youtube.com/playlist?list=PL8ofwN6MZdI_JsyH5qaHA1itUfXa7w8sR ► Programming with RFEM 6 and Python: https://www.youtube.com/playlist?list=PLx7dtCtXeyHWXCU3Q6NMHkKwRgWgLb-Da ► RFEM 6 tutorial with Rhino & Grasshopper: https://www.youtube.com/playlist?list=PLx7dtCtXeyHX5toT2EXyV5nvc0E0fHWKJ Take advantage of our free support. Do you have any questions? ► Frequently Asked Questions (FAQ): https://www.dlubal.com/en/support-and-learning/support/faq ► Ask an individual question: https://www.dlubal.com/en/support-and-learning/support/ask-individual-question ► Knowledge Base: https://www.dlubal.com/en-US/support-and-learning/support/knowledge-base Follow us and stay up to date: ► Subscribe to the Dlubal YouTube Channel: https://www.youtube.com/user/DlubalEN?sub_confirmation=1 ► Instagram: https://www.instagram.com/dlubal_software/ ► Are you also on Facebook? Follow us here: https://www.facebook.com/dlubal.software.english Keywords #DlubalFAQ #OverstrengthFactor #ASCE7 #LoadCombination #SeismicLoadCase #Earthquake #LimitStateType #DesignSituation #FrequentlyAskedQuestion #FAQAboutDlubalSoftware #QuestionAndAnswerToDlubalSoftware

00:00:50

FAQ 005299 | How do I apply the ASCE 7 Orthogonal Directional Combination procedure (100% + 30% r...

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13 views 1 week ago

,Question: How do I apply the ASCE 7 Orthogonal Directional Combination procedure (100% + 30% rule) to my seismic load in a static analysis? Answer: 1) The default orthogonal combination factor is set to 0.3 (30%). This value can be changed by going to ''Edit Parameters of Edition'' in the ''Load Cases & Combinations'' (Image 1) ► Image | Orthogonal Combination Factor https://www.dlubal.com/en/img/033526 2) Under the ''Load Cases'' tab, create the seismic load cases in the X and Y directions with Qe as the ''Action Category''. Activate the 'Additional Settings| Consider X and Y independently' option. Then, specify the direction under the ''Additional Settings'' tab (Image 2) ► Image | Seismic Load Cases https://www.dlubal.com/en/img/033527 3) Under the ''Design Situations'' tab, select the ''Edit Combination Wizard'' button. In the ''Standard Options'' tab, make sure that the ''Include orthogonal combinations'' option is activated (Image 3) ► Image | Include Orthogonal Combinations Option https://www.dlubal.com/en/img/033528 4) The generated COs including the orthogonal combination factor are listed in the ''Load Combinations'' tab (Image 4) ► Image | Generated COs with Orthogonal Combination Factor https://www.dlubal.com/en/img/033529 For more information, go to the FAQ page: ► https://www.dlubal.com/en-us/support-and-learning/support/faq/005299 Did you find this video helpful? ► Let us know in the comments if you like this video. E-learning videos: ► RFEM 6 for beginners: https://www.youtube.com/playlist?list=PL8ofwN6MZdI_JsyH5qaHA1itUfXa7w8sR ► Programming with RFEM 6 and Python: https://www.youtube.com/playlist?list=PLx7dtCtXeyHWXCU3Q6NMHkKwRgWgLb-Da ► RFEM 6 tutorial with Rhino & Grasshopper: https://www.youtube.com/playlist?list=PLx7dtCtXeyHX5toT2EXyV5nvc0E0fHWKJ Take advantage of our free support. Do you have any questions? ► Frequently Asked Questions (FAQ): https://www.dlubal.com/en/support-and-learning/support/faq ► Ask an individual question: https://www.dlubal.com/en/support-and-learning/support/ask-individual-question ► Knowledge Base: https://www.dlubal.com/en-US/support-and-learning/support/knowledge-base Follow us and stay up to date: ► Subscribe to the Dlubal YouTube Channel: https://www.youtube.com/user/DlubalEN?sub_confirmation=1 ► Instagram: https://www.instagram.com/dlubal_software/ ► Are you also on Facebook? Follow us here: https://www.facebook.com/dlubal.software.english Keywords #DlubalFAQ #ASCE7LoadCombination #LoadCombination #SeismicLoad #OrthogonalCombination #100/30Rule #FrequentlyAskedQuestion #FAQAboutDlubalSoftware #QuestionAndAnswerToDlubalSoftware

00:04:28

How to Create Round Logo Using Canva

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00:02:17

WIN | 11/2024 – What's New in RFEM 6 and RSTAB 9?

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274 views 2 weeks ago

,In this short video, we present the most important new features of the past month. We will introduce you to the latest features of the successful structural analysis software by Dlubal! In October 2024, the following features were added to RFEM 6 and RSTAB 9, which will facilitate your work in the future: 00:00 Internal forces for welds 00:16 Concrete Foundations add-on 00:48 Wind load wizard according to SANS 10160:2019 01:11 Interactive comments 01:43 Initial state for time history analysis Further features are listed in the extranet. ► https://external-crm.dlubal.com/extranet.aspx?login=1&language=&form=0&id=0&viewpage=126 Download a free trial version of our programs now: ► Download free 90-day trial: https://www.dlubal.com/en-US/downloads-and-information/free-trial-versions/download-trial-versions Did you find this video helpful? ► Then we would appreciate your comments and likes. E-Learning Videos: ► RFEM 6 for Beginners: https://www.youtube.com/playlist?list=PL8ofwN6MZdI_JsyH5qaHA1itUfXa7w8sR ► Programming with RFEM 6 and Python: https://www.youtube.com/playlist?list=PL8ofwN6MZdI85JiM-9rcL_x47muHsoqR6 ► RFEM 6 Tutorial with Rhino & Grasshopper: https://www.youtube.com/playlist?list=PL8ofwN6MZdI9kCA-3urTuraG1HW1jK3MO Take advantage of our free support. Do you have any questions? ► Frequently Asked Questions (FAQ): https://www.dlubal.com/en-US/support-and-learning/support/faq ► Ask Individual Question: https://www.dlubal.com/en-US/support-and-learning/support/ask-individual-question ► Knowledge Base: https://www.dlubal.com/en-US/support-and-learning/support/knowledge-base Follow us and stay up to date: ► Subscribe to the Dlubal YouTube Channel: https://www.youtube.com/user/DlubalEN?sub_confirmation=1 ► Instagram: https://www.instagram.com/dlubal_software/ ► Are you also on Facebook? Follow us here: https://www.facebook.com/dlubal.software.english Keywords #DlubalUpdate #WeldForces #InternalForces #ConcreteFoundations #EN1997 #EN1992 #Eurocode7 #Eurocode2 #WindLoadsAccordingToSouthAfricanStandard #InteractiveComments #InitialState #THA #TimeHistoryAnalysis #NewCustomerVersion #What'sNewAtDlubal #What'sNewInRFEM6 #What'sNewInRSTAB9 #UpdateReport #Release #Construction #CivilEngineering #StructuralEngineer #StructuralDesign #StructuralDesigner #StructuralAnalysis #RFEM6 #RSTAB9 #DlubalSoftware

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mRNA Vaccines - Researchers Propose A Design Fix

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,mRNA Vaccines - Researchers Propose A Design Fix An article on University of Cambridge contains this statement, "Researchers have discovered that misreading of therapeutic mRNAs by the cell’s decoding machinery can cause an unintended immune response in the body. They have identified the sequence within the mRNA that causes this to occur and found a way to prevent ‘off-target’ immune responses to enable the safer design of future mRNA therapeutics." If you like this content and want more, I am doing a special lifetime membership offer. Click here: https://www.drbeen.com/yt-special/ Want to support this work?: Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true PayPal: https://paypal.me/mobeensyed?locale.x=en_US My substack: https://mobeensyedmd.substack.com/ #drbeen #koolbeens #COVID Disclaimer: This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only. Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. URL list from Friday, Dec. 8 2023 Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses | University of Cambridge https://www.cam.ac.uk/research/news/researchers-redesign-future-mrna-therapeutics-to-prevent-potentially-harmful-immune-responses N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting | Nature https://www.nature.com/articles/s41586-023-06800-3 The Shape and Structure of Proteins - Molecular Biology of the Cell - NCBI Bookshelf https://www.ncbi.nlm.nih.gov/books/NBK26830/#:~:text=A%20protein%20molecule%20is%20made,one%20molecule%20to%20the%20next. Ribosomes, Transcription, Translation | Learn Science at Scitable https://www.nature.com/scitable/topicpage/ribosomes-transcription-and-translation-14120660/#:~:text=Recall%20that%20mRNA%20molecules%20are,protein%20as%20it%20is%20synthesized. Genetic code - Wikipedia https://en.wikipedia.org/wiki/Genetic_code DNA and RNA codon tables - Wikipedia https://en.wikipedia.org/wiki/DNA_and_RNA_codon_tables Pseudouridine - Wikipedia https://en.wikipedia.org/wiki/Pseudouridine Modifications in an Emergency: The Role of N1-Methylpseudouridine in COVID-19 Vaccines | ACS Central Science https://pubs.acs.org/doi/10.1021/acscentsci.1c00197 Ribonucleotide - Wikipedia https://en.wikipedia.org/wiki/Ribonucleotide#:~:text=In%20biochemistry%2C%20a%20ribonucleotide%20is,monomeric%20building%20blocks%20for%20RNA. Translation: DNA to mRNA to Protein | Learn Science at Scitable https://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393/#:~:text=The%20process%20of%20translation%20can,transcription%20as%20well%20as%20tRNA.&text=The%20genes%20in%20DNA%20encode,the%20functions%20necessary%20for%20life. Frontiers | On programmed ribosomal frameshifting: the alternative proteomes https://www.frontiersin.org/articles/10.3389/fgene.2012.00242/full#:~:text=Frameshifting%20is%20a%20process%20whereby,downstream%20(%E2%88%921%20frameshift).