Understanding Inflammatory Pathways and How Supplements Can Help
In this video, we dive into the fascinating world of inflammation and explore the main pathways that play a crucial role in the body's response to injury or infection. We discuss the:
My article capturing this information: https://www.drbeen.com/articles/understanding-inflammatory-pathways-and-how-supplements-can-help/
Following pathways and supplements to modulate these are presented in this talk:
Arachidonic Acid Pathway
JAK-STAT Pathway
MAPK Pathway
NF-κB Pathway
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Timestamps:
0:00 - Introduction to Inflammatory Pathways
0:34 - Pathways
2:39 - Supplements
Further Reading and References:
NF-kB and Jak-STAT pathway suppression
Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic
https://academic.oup.com/abbs/article/47/3/207/1754742
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784227/
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review - PubMed
https://pubmed.ncbi.nlm.nih.gov/32157749/
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity1 | The Journal of Immunology | American Association of Immunologists
https://journals.aai.org/jimmunol/article/163/6/3474/32577/Curcumin-Blocks-Cytokine-Mediated-NF-B-Activation
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
Arachidonic Acid Pathway
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537720/
MAPK Pathway
Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S266726852300058X
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
,,-gsLxPagNB8,UCrtd2wePvAl6RN_D-9jWVQQ, Health,Knowledge, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_-gsLxPagNB8,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,,hRCac7xcAtg,UCrtd2wePvAl6RN_D-9jWVQQ, Health, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_hRCac7xcAtg,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
If you like this content and want more, I am doing a special membership offer. Click here:
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
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#drbeen #Inflammation #Supplements
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
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#drbeen #Inflammation #VitaminD
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
,1,Understanding Inflammatory Pathways and How Supplements Can Help
In this video, we dive into the fascinating world of inflammation and explore the main pathways that play a crucial role in the body's response to injury or infection. We discuss the:
My article capturing this information: https://www.drbeen.com/articles/understanding-inflammatory-pathways-and-how-supplements-can-help/
Following pathways and supplements to modulate these are presented in this talk:
Arachidonic Acid Pathway
JAK-STAT Pathway
MAPK Pathway
NF-κB Pathway
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #HealthPolicy
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Timestamps:
0:00 - Introduction to Inflammatory Pathways
0:34 - Pathways
2:39 - Supplements
Further Reading and References:
NF-kB and Jak-STAT pathway suppression
Anti-inflammatory effect of resveratrol through the suppression of NF-κB and JAK/STAT signaling pathways | Acta Biochimica et Biophysica Sinica | Oxford Academic
https://academic.oup.com/abbs/article/47/3/207/1754742
Curcumin Regulates Anti-Inflammatory Responses by JAK/STAT/SOCS Signaling Pathway in BV-2 Microglial Cells - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784227/
Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review - PubMed
https://pubmed.ncbi.nlm.nih.gov/32157749/
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity1 | The Journal of Immunology | American Association of Immunologists
https://journals.aai.org/jimmunol/article/163/6/3474/32577/Curcumin-Blocks-Cytokine-Mediated-NF-B-Activation
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
Arachidonic Acid Pathway
Omega-3 PUFAs Lower the Propensity for Arachidonic Acid Cascade Overreactions - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537720/
MAPK Pathway
Omega-3 fatty acids mediated Cellular signaling and its regulation in Human Health - ScienceDirect
https://www.sciencedirect.com/science/article/pii/S266726852300058X
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0169328X05002998
,1,Manny Puig is a legendary wildlife expert, hunter, & fisherman who became widely known for his hands-on approach when dealing with deadly predators such as sharks, rattle snakes, black bears and alligators. He has made frequent appearances on the television shows Jackass and Wildboyz as well as the Animal Planet show Gator Boys.
EPISODE LINKS
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,1,Pain and Why it Becomes Chronic? (Lecture 1)
In 2021 about 56 million US adults experienced chronic pains. 17 million experienced high-impact chronic pains. Pandemic has contributed to a significant new cases. We are starting a series to understand what pain is, the anatomy, physiology, pathology, and the management aspects will be covered in this mini-series on pain. Let's start with pain, pain transduction, pain pathways, and pain modulation in this talk.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special-p/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
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#drbeen #koolbeens #PAIN
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References
DrBeen.Com
Chronic Pain Among Adults — United States, 2019–2021 | MMWR
https://www.cdc.gov/mmwr/volumes/72/wr/mm7215a1.htm
The Revised IASP definition of pain: concepts, challenges, and compromises - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680716/
Untitled Document
https://www.rnceus.com/ages/nociceptive.htm
The Anatomy and Physiology of Pain - Pain and Disability - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK219252/
Physiology, Enkephalin - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK557764/
Pain Modulation - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/pain-modulation
The Anatomy and Physiology of Pain - Pain and Disability - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK219252/
Pain Tracts and Sources (Section 2, Chapter 7) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston
https://nba.uth.tmc.edu/neuroscience/m/s2/chapter07.html
Therapeutic Basis of Clinical Pain Modulation - Kirkpatrick - 2015 - Clinical and Translational Science - Wiley Online Library
https://ascpt.onlinelibrary.wiley.com/doi/pdf/10.1111/cts.12282
Pain Tracts and Sources (Section 2, Chapter 7) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston
https://nba.uth.tmc.edu/neuroscience/m/s2/chapter07.html
The Anatomy and Physiology of Pain - Pain and Disability - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK219252/#:~:text=The%20pathway%20for%20pain%20transmission,is%20derived%20from%20animal%20studies.
Pain Modulation - an overview | ScienceDirect Topics
https://www.sciencedirect.com/topics/medicine-and-dentistry/pain-modulation
Untitled Document
https://www.rnceus.com/ages/nociceptive.htm
Physiology, Enkephalin - StatPearls - NCBI Bookshelf
https://www.ncbi.nlm.nih.gov/books/NBK557764/
Moving Beyond Pain as the Fifth Vital Sign and Patient Satisfaction Scores to Improve Pain Care in the 21st Century - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5878703/
,1,Harvey Silverglate is a free speech advocate, co-founder of FIRE, the Foundation for Individual Rights in Expression, and author of several books on freedom of speech and criminal justice. He is running for Harvard Board of Overseers on a platform of free speech. If you're a Harvard Alumni, please consider voting for him by Tue, May 16, 5pm ET: https://www.harvey4harvard.com/ballot Please support this podcast by checking out our sponsors:
- Factor: https://factormeals.com/lex50 and use code lex50 to get 50% off first box
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EPISODE LINKS:
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PODCAST INFO:
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Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41
OUTLINE:
0:00 - Introduction
2:15 - Freedom of speech
23:56 - Bureaucracy in Universities
40:10 - Clash of ideas
43:48 - Public education is broken
55:24 - Jeffrey Epstein
1:08:17 - Freedom of thought and liberal arts
1:19:22 - Interviewing controversial people
1:23:06 - Alan Dershowitz
1:26:19 - Donald Trump
1:33:18 - FBI
1:41:43 - Criminal justice system
1:44:12 - Advice
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,1,Paul Rosolie is a conservationist, explorer, author, filmmaker, real life Tarzan, and founder of Junglekeepers which today protects over 50,000 acres of threatened habitat. Please support this podcast by checking out our sponsors:
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PODCAST INFO:
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Full episodes playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOdP_8GztsuKi9nrraNbKKp4
Clips playlist: https://www.youtube.com/playlist?list=PLrAXtmErZgOeciFP3CBCIEElOJeitOr41
OUTLINE:
0:00 - Introduction
2:33 - Amazon rainforest
13:47 - Discovery of the Amazon
18:24 - Werner Herzog
24:30 - Jane Goodall
38:19 - Anacondas
1:02:08 - Eaten Alive
1:14:32 - Joe Rogan
1:22:51 - Surviving in the Amazon
1:50:03 - Uncontacted tribes in the Amazon
1:59:58 - Surrounded by black caiman crocodiles
2:17:35 - Graham Hancock and ancient civilizations
2:23:06 - Aliens
2:53:08 - Climate change
2:58:19 - Jordan Peterson
3:15:41 - Hunting
3:22:57 - Ayahuasca
3:31:24 - Meaning of life
SOCIAL:
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,1,Matthew Cox is a former mortgage broker and fraudster who swindled over $11 million in mortgages and was sentenced to 26 years in federal prison. Today he is an author, writer, & podcaster.
EPISODE LINKS
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OUTLINE
0:00 - Matt got married
4:24 - Being chased by Secret Service & FBI
28:08 - How Matt snitched on a Ponzi scheme kingpin for a 5 year sentence reduction
44:15 - Moral code & the art of being a snitch
52:55 - Matt’s rise to super stardom
55:12 - Matt’s Bodybuilding / Testosterone protocol
57:42 - Chinese microchip robbers of Silicon Valley
1:02:19 - China / Taiwan conflict
1:11:10 - Russia / Ukraine war
1:33:38 - Is America a late stage empire?
1:37:38 - When will we become a Type-2 civilization?
1:45:48 - Matt’s testosterone levels
2:05:50 - Pierre Rausini
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,1,Penile Fractures and More Holiday Injuries
If every day was Christmas there will be 43% more penile fractures. Let's look at this new German study and also be aware of holiday injuries.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special/
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#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Dec. 22 2023
DrBeen: Online Personalized Medical Education - DrBeen
https://www.drbeen.com/
Penile Fracture - Clinical Features - Emergency Management - TeachMeSurgery
https://teachmesurgery.com/urology/other/penile-fracture/
Risk of penile fractures rises at Christmas, doctors find | Christmas | The Guardian
https://www.theguardian.com/lifeandstyle/2023/dec/20/risk-of-penile-fractures-rises-at-christmas-doctors-find#:~:text=They%20have%20discovered%20that%20the,during%20over%2Denthusiastic%20sexual%20intercourse.
Penile fractures: the price of a merry Christmas
https://bjui-journals.onlinelibrary.wiley.com/doi/epdf/10.1111/bju.16216
,1,SUPPORT ME ON PATREON!
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SUBSCRIBE TO ME ON RUMBLe!
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MY STORY ON GOING BLIND & HOW I OPERATE MY VIDEO MINISTRY
https://youtu.be/a76J4eYJHyo
,1,Lahore in Pakistan’s east has seen flight cancellations, school closures, factory shutdowns, and artificial rain to get pollution under control — but nothing seems to be working. Some are calling for greater cross-border cooperation with India to address the problem.
Read the full story here: https://bit.ly/3S9zggu
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This video may be available for archive licensing via https://newsroom.ap.org/home
,1,A FedEx pilot records a UFO but the evidence is weak. This time the story is better than the video. What was it?
-------------------------------------------
LINKS TO VIDEOS PLAYED
THIRDPHASEOFMOON -
SUPER CLEAR UFO footage JUST IN! What On Earth Are They? 2023 - https://www.youtube.com/watch?v=K3VC14vbY2g
THAT IS IMPOSSIBLE -
Mind Blowing Phenomena Viewers Are Struggling To Explain - https://www.youtube.com/watch?v=9_W4VfrfsnM
TUZLA TUZLA - (FEDEX VIDEO)
Real UFO video from FedEx plane - https://www.youtube.com/watch?v=EXvHzgqGULs
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On January 10, 2022, my US Army insider, JP, revealed that he participated in a classified mission to an extraterrestrial space ark located under the Atlantic Ocean off the Florida coast in the vicinity of Bermuda. This was the second space ark that he has encountered in covert military missions – the first involved a space ark found on the Moon, as reported in an earlier article.
,1,(14 Jan 2024) Giorgio Armani shows a mariner-inspired collection at Milan fashion week. (Jan. 14)
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