What Are Cancers? Cancer Immunology (Part 2) with Prof. Dr. William Murphy
Dr. William J. Murphy is a scientist with extensive experience with immune and the cancer system interactions. Dr. Murphy has graciously offered to help us understand cancer immunology.
Today we will focus more on the CAR-T therapy.
Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References with some previous talks
COVID Research - A Talk With Dr. William J. Murphy - YouTube
https://www.youtube.com/watch?v=UdmaZX3ftfY
Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Autoimmune Disease after Infection or Vaccine in Some (Article Review of Anti-idiotype Antibodies) - YouTube
https://www.youtube.com/watch?v=kE9UUX7NV5Q
,,-gsLxPagNB8,UCrtd2wePvAl6RN_D-9jWVQQ, Health,Knowledge, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_-gsLxPagNB8,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,,hRCac7xcAtg,UCrtd2wePvAl6RN_D-9jWVQQ, Health, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_hRCac7xcAtg,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
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#drbeen #Inflammation #Supplements
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
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#drbeen #koolbeens #Health #omega3
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
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,1,Far-right speaker, Candace Owens, gets triggered by many things including Harry Styles and Kanye West backlash when talking to Fox News host, Tucker Carlson. John Iadarola, Francesca Fiorentini and Aida Rodriguez break it down on The Damage Report.
Read more here:
The Peter Thiel-Backed Conservative Dating App ‘The Right Stuff’ Is Live And The Jokes Are Flying - https://uproxx.com/viral/the-right-stuff-conservative-dating-app-live-twitter-reactions/?utm_source=pocket_mylist
"Just in time for Donald Trump’s Twitter clone to hit still more bad times, here’s “The Right Stuff.” No, not the longtime neo-Nazi site of the same name. It’s the conservative dating app — founded by Trump aide John McEntee, funded by right wing venture capitalist Peter Thiel — that was threatened earlier this year. Expected to bow last summer, it instead landed in early fall, complete with a new ad. Alas, if anyone involved in the new app thought they could escape social media mockery, they were wrong.
The spot features a variety of women in talking about what they’re looking for in a man (not a woman, of course). “They just have to be a conservative,” one says, revealing a fairly low bar. Another says she likes “the alpha-male vibe.” On the subject of why they want to date conservatives, one woman says that rightwingers “know how to treat a woman,” while another says they have “better manners.” “I like that they understand their role in the relationship as a man,” yet another says, which seems like a pretty dog-whistle-y statement.
It didn’t take long for people to make parodies of the ad, juxtaposing some of the women’s responses with unflattering images of actual GOP men."
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,1,Brandon Novak pro skateboarder, speaker, author, & best friend of Bam Margera. He is known for his appearances on Viva La Bam, Jackass, the CKY series & Haggard.
EPISODE LINKS
https://brandonnovak.com
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OUTLINE:
00:00 - Brandon & Bam in the early days
06:00 - How Brandon got into heroin so early?
09:40 - Brandon's memory is shot
12:55 - Ali Boulala & the Piss Drunx crew
20:01 - Avoiding drugs and alcohol
22:14 - Brandon's quest to sobriety
26:08 - Intentionally sabotaging his own success
29:32 - Insane story behind the ALF tattoo
33:02 - Filming Viva La Bam for MTV
37:53 - Putting a rock up his butt for drug money
41:31 - CKY stories
42:50 - Twisted stories trying to score smack
44:37 - Brandons mom prayed for his death
49:45 - Working for the DEA
58:26 - Fentanyl
01:01:57 - What's a "Speed-ball" ?
01:03:51 - Cartel wars
01:06:40 - Disturbing hotel experience in Australia
01:14:43 - Novak's relationship with Bam
01:19:57 - Novak's Houses for the Recovering
01:28:31 - Psychological affect of giving
01:32:47 - Methadone clinics
01:41:49 - Experiments with good vices
01:46:51 - The most FOUL tattoo in history
01:51:44 - Conflict
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Eric Wargo has a Ph.D. in anthropology from Emory University and works as a professional science writer and editor in Washington, D.C. He is the author of the acclaimed book Time Loops.
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OUTLINE
00:00 - psychology study on precognition
14:03 - precognitive dreams
30:50 - why we forget our dreams
33:16 - J.W. Dunne's precognitive dream protocol
40:40 - dreams predicted 9/11
50:35 - famous precognitive dreams
01:00:21 - precognitive day dreams & thoughts
01:03:07 - where our ideas come from
01:18:41 - remote viewing & trained precognition
01:25:18 - Retrocausality
01:36:55 - free will is a myth
01:48:12 - our 4-dimensional universe
02:02:20 - who is gifted with precognition
02:12:31 - lucid dreams & astral projections
,1,(1 Jan 2024) Today In History 0101
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,1,(27 Dec 2023) Najiah Knight is a 17-year-old bull rider with a big dream. She wants to be the first woman to compete at the top level of the Professional Bull Riders tour. (Dec. 27) (AP video: Ty O'Neil, Amanda Loman, Carrie Antlfinger)
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,1,What Are Cancers? Cancer Immunology (Part 2) with Prof. Dr. William Murphy
Dr. William J. Murphy is a scientist with extensive experience with immune and the cancer system interactions. Dr. Murphy has graciously offered to help us understand cancer immunology.
Today we will focus more on the CAR-T therapy.
Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References with some previous talks
COVID Research - A Talk With Dr. William J. Murphy - YouTube
https://www.youtube.com/watch?v=UdmaZX3ftfY
Dr. William J. Murphy, Ph.D. for UC Davis Health
https://health.ucdavis.edu/team/search/1226/william-murphy---cancer---dermatology---hematology-oncology---pathology---dermatopathology-sacramento
A Possible Role for Anti-idiotype Antibodies in SARS-CoV-2 Infection and Vaccination | NEJM
https://www.nejm.org/doi/full/10.1056/NEJMcibr2113694
Autoimmune Disease after Infection or Vaccine in Some (Article Review of Anti-idiotype Antibodies) - YouTube
https://www.youtube.com/watch?v=kE9UUX7NV5Q
