Pancreatic Cancer Vaccines With Amazing Results in Phase I
Pancreatic ductal adenocarcinoma is one of the most lethal cancers with a 5 year survival rate of less than 10%. mRNA designer/personalized vaccines are changing this situation. Let's review the results of phase I trials.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Jun. 4 2024 11:37 AM
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches | Radiation Oncology | Full Text
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-019-1345-6
NHS England Thousands of NHS patients to access trials of personalised cancer ‘vaccines’
https://www.england.nhs.uk/2024/05/thousands-of-nhs-patients-to-access-trials-of-personalised-cancer-vaccines/
Three-year Phase 1 Follow-Up Data for mRNA-based Individualized Immunotherapy Candidate Show Persistence of Immune Response and Delayed Tumor Recurrence in Some Patients with Resected Pancreatic Cancer | BioNTech
https://investors.biontech.de/news-releases/news-release-details/three-year-phase-1-follow-data-mrna-based-individualized
Investigational mRNA Vaccine Induced Persistent Immune Response in Phase 1 Trial of Patients With Pancreatic Cancer | Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out
Trial Design
https://www.biontech.com/int/en/home/pipeline-and-products/clinical-trials-new/trial-design.html
Cancer vaccines are having a renaissance | MIT Technology Review
https://www.technologyreview.com/2024/05/03/1092026/cancer-vaccines-are-having-a-renaissance/
NHS England launches scheme to boost signups for personalised cancer vaccine trials | The BMJ
https://www.bmj.com/content/385/bmj.q1212#:~:text=The%20vaccines%20currently%20being%20trialled,identify%20and%20destroy%20cancer%20cells.
,,-gsLxPagNB8,UCrtd2wePvAl6RN_D-9jWVQQ, Health,Knowledge, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_-gsLxPagNB8,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
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#drbeen #koolbeens #diabetes
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,,hRCac7xcAtg,UCrtd2wePvAl6RN_D-9jWVQQ, Health, channel_UCrtd2wePvAl6RN_D-9jWVQQ, video_hRCac7xcAtg,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
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#drbeen #Inflammation #Supplements
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
,1,New York City runs on street food. That’s why our grub-loving vloggers are naming their favorite food trucks across the city. Perhaps most famous is The Halal Guys, known for their “melt-in-you-mouth” meat. Other picks span the boroughs and the globe, from Bangladesh to Greece to Mexico to Hong Kong. Find out if your go-to "drunk food" made the list here.
WATCH THE FULL EPISODE HERE: https://youtu.be/zZqlHLcZMj4
#nyc #foodtrucks #tacos #gyros #halalguys #fuskahouse #kingsouvlaki #birrialandia #xiangminicakes
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,1,The Ukraine and Russia war hoax as shown in I, Pet Goat 2. This video is taken from a section that starts at 3:33 in the main I Pet Goat II. The code for WW3 is 333. So, it's very interesting that it's this moment in the video that we see the hammer and sickle, the tiger on the girls back for 2022 and the nuclear war symbol on her face in the Ukraine colours of blue and yellow. Those are also the Masonic colours.
,1,Many Legal COVID Thoughts by Paul Bork
As promised Paul Bork will discuss the COVID related legal landscape. We will continue this series of legal landscape review if you liked it.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,Joe Biden And Ron DeSantis Take On Donald Trump | Joe Biden Live | Biden Vs Trump | News18 Live
2 Impeachments, 4 criminal probes & 2 serious charges later, Donald Trump is stronger than ever before. If trump becomes GOP's nominee, he has a big chance to defeat Joe Biden. Can analysts deny Trump's popularity? What does it say about U.S. politics?
#joebiden #desantis #donaldtrump #usnewslive
n18oc_world
,1,Bestselling author and popular speaker Suneel Gupta knows what it's like to fail and to succeed. He's done both, and he says the key to creating a balanced, joyous life that integrates ambition, work and well-being is to find your dharma—your inner calling.
He says we’ve been conditioned, from an early age, to believe that one day we’ll reach a moment of “arrival.” But no matter how much we achieve or acquire we still don’t feel as satisfied or as fulfilled as we thought we would be. Exhausted, we become burned out and cynical, questioning the purpose of it all.
An expert on happiness and work, Gupta argues that for too long we have compartmentalized work and well-being and ignored the fact that both are essential for sustained success. We’ve assumed that outer success leads to inner well-being, despite history showing us otherwise.
In his latest book, Everyday Dharma, Gupta weaves personal stories, history, science, Eastern philosophy, and Western modalities in this prescriptive book.
Gupta, a visiting scholar at Harvard Medical School, will share his ideas for empowering people to let go of anxiety, follow their ambitions, produce their life’s work, and experience true joy.
Gupta photo by Emily Rose Photography.
September 25, 2023
Suneel Gupta
Founding CEO of RISE; Co Founder of the Gross National Happiness Center in the United States; Author, Everyday Dharma: 8 Essential Practices for Finding Success and Joy in Everything You Do
In Conversation with DJ Patil
Former U.S. Chief Data Scientist; General Partner, GreatPoint Ventures; Member, The Commonwealth Club of California Board of Governors
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,1,Pancreatic Cancer Vaccines With Amazing Results in Phase I
Pancreatic ductal adenocarcinoma is one of the most lethal cancers with a 5 year survival rate of less than 10%. mRNA designer/personalized vaccines are changing this situation. Let's review the results of phase I trials.
Want to get access to DrBeen at low price of $4.99/month? Click here: https://www.drbeen.com/med-nerd/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
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My substack: https://mobeensyedmd.substack.com/
#drbeen #koolbeens #HealthPolicy
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
URL list from Tuesday, Jun. 4 2024 11:37 AM
Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches | Radiation Oncology | Full Text
https://ro-journal.biomedcentral.com/articles/10.1186/s13014-019-1345-6
NHS England Thousands of NHS patients to access trials of personalised cancer ‘vaccines’
https://www.england.nhs.uk/2024/05/thousands-of-nhs-patients-to-access-trials-of-personalised-cancer-vaccines/
Three-year Phase 1 Follow-Up Data for mRNA-based Individualized Immunotherapy Candidate Show Persistence of Immune Response and Delayed Tumor Recurrence in Some Patients with Resected Pancreatic Cancer | BioNTech
https://investors.biontech.de/news-releases/news-release-details/three-year-phase-1-follow-data-mrna-based-individualized
Investigational mRNA Vaccine Induced Persistent Immune Response in Phase 1 Trial of Patients With Pancreatic Cancer | Memorial Sloan Kettering Cancer Center
https://www.mskcc.org/news/can-mrna-vaccines-fight-pancreatic-cancer-msk-clinical-researchers-are-trying-find-out
Trial Design
https://www.biontech.com/int/en/home/pipeline-and-products/clinical-trials-new/trial-design.html
Cancer vaccines are having a renaissance | MIT Technology Review
https://www.technologyreview.com/2024/05/03/1092026/cancer-vaccines-are-having-a-renaissance/
NHS England launches scheme to boost signups for personalised cancer vaccine trials | The BMJ
https://www.bmj.com/content/385/bmj.q1212#:~:text=The%20vaccines%20currently%20being%20trialled,identify%20and%20destroy%20cancer%20cells.
,1,In connection with the pushing back of Ukrainian forces in Lugansk and the complete liberation of the republic from the Bandera invaders, Zelensky signed an Instrument of unconditional surrender. t.me/RKadyrov_95 posted the record from the office first.
With the help of well-known pranksters Vovan and Lexus t.me/Russiacalling, as well as t.me/comicadzeofhumor.
To be continued...
В связи с оттеснением украинских сил в Луганске и полным освобождением республики от бандеровских оккупантов Зеленский подписал акт о безоговорочной капитуляции. Запись из рабочего кабинета опубликовал первым t.me/RKadyrov_95.
Процедура не обошлась без помощи известных всем пранкеров Вована и Лексуса t.me/Russiacalling, а также t.me/comicadzeofhumor.
Продолжение следует...
Credits: https://t.me/more_on_ukraine/2586
✅My channels:
(More information is on Telegram)
𝗧𝗲𝗹𝗲𝗴𝗿𝗮𝗺: https://t.me/more_on_ukraine
(Videos banned from Youtube are available on Odysee)
𝗢𝗱𝘆𝘀𝗲𝗲: https://odysee.com/@TheTruthSeeker:d
Youtube: https://www.youtube.com/c/TheTruthSeekerYT
,1,Tuesday, 06/25/2024 | with Brianna Lyman | https://live.oann.com
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