,physiology,nursing,NCLEX,health,disease,biology,medicine,nurse education,medical education,pathophysiology,campbell,human biology,human body,S_SnY1A6P84,, Society, channel_UCF9IOB2TExg3QIBupFtBDxg, video_S_SnY1A6P84,Well, this talk was scheduled for about 45 minutes, but ended up at nearly two hours.
Link to the full video on John's channel: https://www.youtube.com/watch?v=o9BvqmID724
Link to original video on Jimmy;s channel: https://www.youtube.com/watch?v=mkRWsK6U6GA
,physiology,nursing,NCLEX,health,disease,biology,medicine,nurse education,medical education,pathophysiology,campbell,human biology,human body,o9BvqmID724,, Politics,Society, channel_UCF9IOB2TExg3QIBupFtBDxg, video_o9BvqmID724,Well, this talk was sceduled for about 45 minutes, but ended up at nearly two hours.
Link to original video: https://www.youtube.com/watch?v=mkRWsK6U6GA
,physiology,nursing,NCLEX,health,disease,biology,medicine,nurse education,medical education,pathophysiology,campbell,human biology,human body,-m-HM2hmVSM,, Health,Knowledge, channel_UCF9IOB2TExg3QIBupFtBDxg, video_-m-HM2hmVSM,With Professor Colleen Aldous
Critical appraisal of multidrug therapy in the ambulatory
management of patients with COVID-19 and hypoxemia
Part II: Causal inference using the Bradford Hill criteria
https://www.jstage.jst.go.jp/article/antibiotics/78/1/78_35/_pdf/-char/en
We continue the critical appraisal of three published case series of 119 COVID-19 patients with hypoxemia, treated in the United States, Zimbabwe, and Nigeria with similar ivermectin-based multidrug treatments, to assess the available evidence supporting a causal relationship between treatment and reduction in hospitalizations and mortality. A narrative review was conducted to assess the Bradford Hill criteria for a causal association. We used a previously proposed refinement of the Bradford Hill criteria that reorganized them into three categories of direct, mechanistic, and
parallel evidence. The efficacy of the two most aggressive ivermectin-based
multidrug protocols is supported by the Bradford Hill criteria for temporality,
strength of association, biological gradient, biological plausibility, coherence, consistency, and analogy. The causal relation between the treatment of hypoxemic COVID-19 patients using these protocols and the reduction in hospitalizations and mortality is supported as an inference to the best explanation.
Critical appraisal of multidrug therapy in the ambulatory
management of patients with COVID-19 and hypoxemia
Part I. Evidence supporting the strength of association
https://faculty.utrgv.edu/eleftherios.gkioulekas/papers/032-c19-ivm-oxygen.pdf
On March 11, 2020, Coronavirus Disease 2019 (COVID-19), the disease caused by the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), was declared a pandemic by the World Health Organization (WHO) [1]. Worldwide, 768,187,096 confirmed cases of COVID-19 and 6,945,714 deaths have been reported to the WHO as of June 21 2023, amounting to an average Case Fatality Rate (CFR) of 0.9% [2]. During 2020, while several governments and public health agencies were focused on contagion control and in-hospital patient care, several medical doctors from all around the world innovated and discovered early outpatient multidrug treatments using several repurposed medications in combination [3–15]. In the United States, several independent efforts coalesced into the formulation of a sequenced multidrug protocol [10, Fig. 3] (hereafter, McCullough protocol), which is based on the pathophysiological understanding of COVID-19 as a triphasic illness with three overlapping phases: (1) viral proliferation; (2) hyperinflammatory cytokine storm (COVID-19 pneumonia); and (3) thrombosis. McCullough’s protocol proposed a combination antiviral therapy for treating the viral proliferation phase, immunomodulators for treating the cytokine storm, and antiplatelet agents and antithrombotics for handling the thrombotic stage, based on risk stratification and how the disease presents in each individual patient. Thus, the McCullough protocol is an algorithmic treatment using sequenced multiple drugs in combination and customized to the individual patient and their response to treatment; no single drug is necessary nor sufficient to achieve treatment efficacy towards reducing hospitalizations and deaths. A recently published update of the McCullough protocol [16, Fig. 3] introduced some adjustments including virucidal nasal washes and oral gargles [17–24]. A large case series of 869 high-risk patients [25, 26], who were treated using an early version of the McCullough protocol, has been compared against population-level and historical controls [27], showing the existence of efficacy with respect to the reduction of mortality and hospitalizations, which is also resilient with respect to random selection bias, provided that patients are treated early enough within the first 3 to 5 days from the onset of illness. Indeed, an earlier study by Fazio et al.[28] showed that the ideal window of opportunity for initiating an effective early outpatient treatment of COVID-19 to prevent hospitalization is approximately within the first 3 days.
,physiology,nursing,NCLEX,health,disease,biology,medicine,nurse education,medical education,pathophysiology,campbell,human biology,human body,2cQH5V2pToE,, Health,Lifestyle_(sociology), channel_UCF9IOB2TExg3QIBupFtBDxg, video_2cQH5V2pToE,Isle of Wight mushroom farm, https://www.iwmushrooms.co.uk/
I have no commercial intrest in this but it is where I get my Lion's mane tuncture from and I visited the farm myself, on this video https://www.youtube.com/watch?v=1UTX8SFDlUM
,physiology,nursing,NCLEX,health,disease,biology,medicine,nurse education,medical education,pathophysiology,campbell,human biology,human body,3dnIGqUlluc,, Health,Knowledge, channel_UCF9IOB2TExg3QIBupFtBDxg, video_3dnIGqUlluc,COVID-19 vaccination, all-cause mortality, and hospitalization for cancer: 30-month cohort study in an Italian province
https://pubmed.ncbi.nlm.nih.gov/40881928/
https://pmc.ncbi.nlm.nih.gov/articles/PMC12381369/
https://www.thefocalpoints.com/p/breaking-first-population-wide-study
The rate of first hospitalization for cancer of any site
Unvaccinated group: 0.85%
Vaccinated group (one or more doses): 1.15%
N = 296,015 population
Hospital admission with a cancer diagnosis, 3,124
(p less than 0.001).
Vaccination with at least one dose
Colon-rectal cancer HR: 1.34
Breast cancer HR: 1.54
Bladder cancer HR: 1.62
After three or more vaccine doses
Breast cancer HR: 1.36
Bladder cancer HR: 1.43
All significant
After one dose (180 days after)
Rate of first hospital admissions for cancers
All cancers: up 23% significant
Colorectal: up 34% significant
Lung: down = 10%
Breast: up 54% significant
Uterine: up = 75%
Ovarian: up = 65%
Prostate: up = 1%
Bladder: up 62% significant
Thyroid: up =58%
Haematological: up = 33%
After three dose (180 days after administration of third dose)
All cancers: up = 9%
Colorectal: up = 14%
Lung: down = 5%
Breast: up=36% significant
Uterine: up = 20%
Ovarian: up = 86%
Prostate: down = 3%
Bladder: up=43% significant
Thyroid: down = 3%
Haematological: up = 5%
More about the study
Population-wide cohort analysis
Evaluating the risk of all-cause death and cancer hospitalization by SARS-CoV-2 immunization status.
National Health System official data, entire population, Pescara province, Italy
Followed from June 2021 (six months after the first vaccination) to December 2023.
296,015 residents aged ≥11 years
Hospital admission with a cancer diagnosis, 3,124
16.6% were unvaccinated
83.3% received ≥1 dose
62.2% ≥3 doses.
Compared with the unvaccinated, those receiving ≥1 dose showed a significantly lower likelihood of all-cause death
Cancer hospitalization was significant only among the subjects with no previous SARS-CoV-2 infection
Some cancer risks went down after 1 year (relative to 180 days)
(But breast, ovarian and bladder went up at one year relative to 180 days after 1 vaccine dose)
Given that it was not possible to quantify the potential impact of the healthy vaccinee bias and unmeasured confounders, these findings are inevitably preliminary.
,physiology,nursing,NCLEX,health,disease,biology,medicine,nurse education,medical education,pathophysiology,campbell,human biology,human body,zPs1NYZR2eU,, Health,Knowledge, channel_UCF9IOB2TExg3QIBupFtBDxg, video_zPs1NYZR2eU,The Madness of Crowds
Extraordinary Popular Delusions and the Madness of Crowds (Charles Mackay, 1841).
Economic bubbles
The Love of the Marvellous and the Disbelief of the True
Peculiar Follies
The Crusades
The Witch Mania
The Slow Poisoners
Philosophical Delusions
The Alchemysts
Fortune Telling
The Magnetisers (Frans Mesmer)
Remedy to groupthink
Uphold the right of dissenters to be heard.
Medical journals, actively encourage the discussion of contrarian ideas
Stop punishment for dissenters
Address financial and other conflicts of interest.
Indulge those occupied with “taboo science,” while still adhering to time-tested scientific principles and methods.
Be aware of manipulating psychopaths and sociopaths (JC)
Something is rotten in the Academy. We need to improve.
