Cancer Immunotherapy - CAR-T Cells. (Part 3) with Prof. Dr. William Murphy
Dr. William Murphy Distinguished Prof., Vice Chair of Research for Dermatology and Internal Medicine departments discusses cancer immunotherapy. Following topics are discussed:
What are CAR-T cells?
Empowering the T cells and NK cells against cancers.
Engineering CAR-T cells.
Why T cells?
What cells are the sources of CARs?
How CAR are built?
Mechanism of action.
Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.
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,1,What Are Reactive Oxygen Species and Lipid Species?
Let's understand the foundational components of inflammation reactive oxygen and reactive lipid species.
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,1,Erratum: Quercetin is primarily lipid soluble and weakly water soluble. I have put it in an incorrect category.
Which Antioxidants To Use Together?
As we use antioxidants for aches and pains/inflammation we need to keep in mind the water or lipid solubility of the molecule. Let's review.
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,1,Simple Plan to Control Inflammation
Here is an important list of anti-inflammatory molecules to help manage inflammation.
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#drbeen #Inflammation #Supplements
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References:
Visit articles related to these topics and see the references at the end: https://www.drbeen.com/articles/category/chronic-inflammation/
,1,Vitamin D May Reduce Fiery Death of Cells and Resulting Severe Inflammation
Vitamin D receptor activation leads to reduced pyroptosis, and a shift towards autophagy and apoptosis. Let's review the mechanism of pyroptosis and the studies about vitamin D's role in preventing pyroptosis.
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URL list from Friday, Jun. 21 2024 16:18 PM
Autophagy, Pyroptosis, and Ferroptosis: New Regulatory Mechanisms for Atherosclerosis - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8793783/
Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway - ScienceDirect
https://www.sciencedirect.com/science/article/abs/pii/S0960076020303149
Vitamin D Receptor Inhibits NLRP3 Activation by Impeding Its BRCC3-Mediated Deubiquitination - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6904361/
Pyroptosis: mechanisms and diseases | Signal Transduction and Targeted Therapy
https://www.nature.com/articles/s41392-021-00507-5
Effects of Vitamin D3 Supplementation and Aerobic Training on Autophagy Signaling Proteins in a Rat Model Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10535215/
Apoptosis Induced by Vitamin D Compounds in Breast Cancer Cells Is Inhibited by Bcl-2 but Does Not Involve Known Caspases or p531 | Cancer Research | American Association for Cancer Research
https://aacrjournals.org/cancerres/article/59/19/4848/505530/Apoptosis-Induced-by-Vitamin-D-Compounds-in-Breast
Morphological Features of Organelles during Apoptosis: An Overview - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3972681/
,1,Omega-3 Reduces Chronic Inflammation and Neurosurgical Pain
Two studies demonstrating the power of omega-3 to reduce inflammation and neurosurgical pain.
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Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
Reference:
Omega-3 fatty acids (fish oil) as an anti-inflammatory: an alternative to nonsteroidal anti-inflammatory drugs for discogenic pain - PubMed https://pubmed.ncbi.nlm.nih.gov/16531187/
An Oily Fish Diet Improves Subclinical Inflammation in People at High Cardiovascular Risk: A Randomized Controlled Study - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/
Study Details | Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects | ClinicalTrials.gov https://clinicaltrials.gov/study/NCT01154478
Table - PMC https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199776/table/molecules-26-03369-t001/
University of Naples Federico II - Wikipedia https://en.wikipedia.org/wiki/University_of_Naples_Federico_II
,1,In this episode, we take a look at the Adani vs Hindenburg scandal. What happened, and how could a company lose $130 billion in a matter of days over a few tweets? Was what Hindenburg did legal? In this episode we'll cover all of this. PS: I was sick through half of this recording, so ignore the voice change, I'm only human.
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The Death Jabs = The Ultimate Attack on Trump and the Complete Failure of the Courts in the AZ Election
The vaccines are the ultimate attack on Trump. The liars that created them will blame operation warp speed despite the fact that this entire thing was planned. #deathjab #WEF #CCP The Court FAILED miserably in their duty to apply the law for @KariLake. Pray for #justice in the appeal #Arizona
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,1,Cancer Immunotherapy - CAR-T Cells. (Part 3) with Prof. Dr. William Murphy
Dr. William Murphy Distinguished Prof., Vice Chair of Research for Dermatology and Internal Medicine departments discusses cancer immunotherapy. Following topics are discussed:
What are CAR-T cells?
Empowering the T cells and NK cells against cancers.
Engineering CAR-T cells.
Why T cells?
What cells are the sources of CARs?
How CAR are built?
Mechanism of action.
Brief bio of Dr. Murphy:
My research for the past 30 years has centered on translational studies involving modeling cancer-immune system interactions starting with my earlier studies on NK cells and HSCT in mouse models and later at the National Cancer Institute on their role in cancer immunotherapy which then expanded to issues in immunotherapy in general.
If you like this content and want more, I am doing a special lifetime membership offer. Click here:
https://www.drbeen.com/yt-special/
Want to support this work?:
Buy me a coffee :-) https://www.buymeacoffee.com/DrMobeenSyed
Become my patron: https://www.patreon.com/mobeensyed?fan_landing=true
PayPal: https://paypal.me/mobeensyed?locale.x=en_US
#drbeen #koolbeens #COVID
Disclaimer:
This video is not intended to provide assessment, diagnosis, treatment, or medical advice; it also does not constitute provision of healthcare services. The content provided in this video is for informational and educational purposes only.
Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional.
,1,As the southern border is being invaded by people from AROUND the world, New York Rep. Jerry Nadler decided to call attention to the big concern during a hearing about immigration integrity, security, and enforcement. In his opening remarks, Nadler said, "We need immigrants in this country ... Forget the fact that the farm ... vegetables would rot in the ground if they weren’t being picked by many immigrants — many iIlegal immigrants!” Racist much? Is that really the most important thing to discuss?
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,1,Watch live coverage of the inauguration of Joe Biden as president, and Kamala Harris as vice president.
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Was this the last straw? In this episode, I cover the latest blunder by the failing Harris-Walz campaign, and how it may have massive consequences in the approaching election. Plus more on the mysterious circumstances surrounding the alleged Trump assassin and an epic debate moment everyone missed.
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,1,Blaze Media correspondent Steve Baker and his attorney Bill Shipley join The Glenn Beck Program to explain why Baker pleaded guilty to 4 misdemeanor counts connected to his presence at the Capitol during the Jan. 6 riot. Steve has argued the entire time that he was there as a journalist and did not act violently, and also that the government isn't going after the other 80 or so journalists who were there. He pled guilty, he explains, because he believes that the court wanted to make an example out of him: "The trial is nothing more than a shaming exercise if you're not going to be allowed to present your own case." Baker and Shipley also discuss the possibility of Donald Trump pardoning J6 defendants when he takes office.
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,1,wow just like that the pedophile agenda is winning now the word groomer is a lgbtq homophobic slur...
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,1,As the Justice Department investigates the leak of dozens of classified files, questions arise over the damage to U.S. interests abroad and who's responsible.
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,1,Former Pakistan Army chief General Qamar Javed Bajwa was heckled by an Afghanistan national in France on Sunday during a family trip. The ex-Pakistan Army chief was with his wife when the incident took place.
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